Ex parte DONG et al. - Page 4




             Appeal No. 95-2281                                                                                   
             Application 07/964,548                                                                               


                    The examiner points out that Ayer discloses a fluid                                           
             removable polysaccharide (answer, page 2).  Appellants’                                              
             nonelectrolytes include saccharides (specification, page 10, line                                    
             35 - page 11, line 2).  However, the polysaccharide in the Ayer                                      
             dosage form is in the wall and functions in forming the exit                                         
             means (col. 5, lines 37-43).  The examiner has not explained, and                                    
             it is not apparent, why such a polysaccharide would cause the                                        
             hydrophilic polymer in the compartment to precipitate.                                               
                    The examiner argues that Ayer and appellants both use                                         
             hydroxypropylmethylcellulose, and that one would expect similar                                      
             ingredients to have similar properties (answer, page 3).  The                                        
             deficiency in this argument is that the examiner has not                                             
             established that the compositions of Ayer and appellants include                                     
             similar ingredients, i.e., that they both contain a means for                                        
             causing the hydrophilic polymer to precipitate.                                                      
                    The examiner points out that Ayer discloses a viscous                                         
             solution-suspension, and argues that a suspension is suggestive                                      
             of a precipitation (answer, page 3).  This argument is not well                                      
             taken because the suspension referred to by Ayer is a suspension                                     
             of the drug caused by the presence of polyethylene oxide having                                      
             two specified molecular weight ranges (col. 4, lines 30-51).                                         
             There is no teaching that the hydroxypropylmethylcellulose                                           

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