Appeal No. 95-2851
Application 08/012,379
Appellant’s claimed invention is a method for alleviating the tobacco withdrawal
syndrome in a human by administering to the human a specified amount of a nicotine
metabolite or combination of nicotine metabolites, or their pharmaceutically acceptable
salts, and an article for carrying out the method. Claims 1 and 67 are illustrative and
read as follows:
1. A therapeutic method to alleviate the tobacco withdrawal syndrome in a
human comprising:
administering an amount of a nicotine metabolite or combination of nicotine
metabolites or their pharmaceutically acceptable salts thereof to a human in need of
such treatment, in an amount in the range of 1 to 100 milligrams per kilogram of body
weight of the human per day calculated as the nicotine metabolite or combination of
nicotine metabolites in the free base form that is effective to reduce or eliminate
symptoms of tobacco withdrawal syndrome.
67. An article of manufacture comprising packaging material and a unit dosage
form of a pharmaceutical agent contained within said packaging material, wherein:
said pharmaceutical agent comprises a nicotine metabolite or combination of
nicotine metabolites or their pharmaceutically acceptable salts thereof in an amount
effective to alleviate tobacco withdrawal syndrome, symptoms of nicotine withdrawal
and wherein said packaging material includes instruction means which indicate that
said nicotine metabolite or combination of nicotine metabolites or said pharmaceutically
acceptable salts thereof can be used by a person in the range of 1 to 100 milligrams
per kilogram of body weight of the person per day calculated as the nicotine metabolite
or combination of nicotine metabolites in the free base form for alleviating (a) symptoms
of tobacco withdrawal syndrome, (b) symptoms of nicotine withdrawal, and (c) the
craving associated with the cessation of nicotine use.
THE REFERENCES
References relied upon by the examiner
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