Appeal No. 96-0009
Application 08/104,417
the application.
THE INVENTION
Appellants claim a method of inhibiting the transport of
a neurotransmitter away from a synapse by contacting the
synapse with a recited compound wherein the compound is
capable of inhibiting the uptake of L-glutamate into
synaptosomes and the neurotransmitter is capable of binding a
transporter which binds L-glutamate. Claim 1 is illustrative
and reads as follows:
1. A method of inhibiting the transport
of a neurotransmitter away from a
synapse comprising contacting said synapse with
a compound selected from the group
consisting of compounds having the
structure:
1 3 3 3 3
wherein R = CO R ; P(OR ) ; P(OH)(OR ); SO R ;2 2 3
or CONHR in any combination;3
R = OR , NR , alkyl, or H; and2 3 32
R = alkyl, substituted alkyl, or H,3
wherein the compounds are capable in inhibiting the
uptake of L-glutamate into synaptosomes, and wherein said
2
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