Appeal No. 94-1483
Application No. 07/695,141
the DNA sequence coding for the single chain T cell
receptors.
In addition, the specification indicates at page 12, lines 22
through 31 that:
It should be understood that the methodology
described herein can be used to prepare soluble,
single chain T cell receptors derived from animal
species other than humans, and soluble, single chain
T cell receptors for a wide variety of different
antigens, for example, fluorescein, foreign major
histocompatability molecules (MHC) and peptide
antigens in the context of MHC molecules. These
variations are included within the scope of the
present invention.
In sum, appellants have described a single specific
nucleic acid coding for unique Ti " and $ subunits. In order
to make and use other soluble, single chain polypeptides or
corresponding nucleic acids according to the present
invention, appellants refer one skilled in the art to
conventional "methodology."
As explained in PPG Indus. Inc. v. Guardian Indus. Corp.,
75 F.3d 1558, 1564, 37 USPQ2d 1618, 1623 (Fed. Cir. 1996):
In unpredictable art areas, this court has refused to
find broad generic claims enabled by specifications that
demonstrate the enablement of only one or a few
embodiments and do not demonstrate with reasonable
specificity how to make and use other potential
embodiments across the full scope of the claim. See,
e.g., In re Goodman, 11 F.3d 1046, 1050-52, 29 USPQ2d
2010, 2013-15 (Fed. Cir. 1993); Amgen, Inc. v. Chugai
-11-
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