Appeal No. 94-1483
Application No. 07/695,141
TCRs are further explained at page 2, lines 19 through 31
of the specification as follows:
Each Ti " and $ subunit contains two
extracellular domains, created by intrachain
disulfide bonding of cysteine residues and a carboxy
terminal hydrophobic transmembrane region followed
by 5-6 amino acid cytoplasmic tails. The genes
encoding the T cell receptor are assembled from
separate gene segments, one of which encodes an
invariant carboxy terminal constant region, while
two or three other segments (V, D and J) encode the
variable region of the molecule which recognizes
antigen and MHC. Within the variable region are
three regions of hypervariability that form the
antigen binding pocket.
An indication of the scope of the claims on appeal
appears at page 6, lines 7 through 21 of the specification as
follows:
[T]he biologically active, soluble, single chain T
cell receptor of the present invention binds at
least one antigen which is bound by a T cell
receptor present on the surface of a T lymphocyte of
mammalian origin. Typically, the biologically
active, soluble, single chain T cell receptor is
capable of binding the antigen or antigens it would
bind as a component of a complete T cell receptor,
either alone or in the context of a particular major
histocompatability molecule. However, biologically
inactive single chain T cell receptors also have
value, for example, as immunogens to initiate in a
mammalian host an immune response against a
particular T cell subtype.
A further indication of the scope of the present claims
appears at page 8, lines 14 through 26 of the specification:
-8-
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