Ex parte HORWICH et al. - Page 2




              Appeal No. 1995-2374                                                                                     
              Application 07/673,158                                                                                   


                     Claims 5, 11, and 16 are illustrative of the subject matter on appeal as read as                  
              follows:                                                                                                 
                     5.  A DNA segment consisting essentially of an isolated, non-chromosomal DNA                      
              segment encoding Hsp60, a mitochondrial eucaryotic protein having a molecular weight                     
              between 55,000 and 65,000 by SDS-polyacrylamide gel electrophoresis under denaturing                     
              conditions, wherein the Hsp60                                                                            
                     (a) has at least 80% homology at the amino acid and nucleic acid level with the                   
              sequences shown in Figure 1, and                                                                         
                     (b) interacts with newly synthesized proteins to fold them into their biologically active         
              conformation.                                                                                            
                     11.  A vector capable of autonomous replication in a cell, said vector containing an              
              operatively linked polynucleotide sequence segment that encodes Hsp60.                                   
                     16.  A transformed host cell containing a vector that autonomously replicates                     
              therein, said vector containing an operatively linked polynucleotide sequence segment that               
              encodes Hsp60.                                                                                           

                     The examiner has not relied upon prior art in rejecting the claims on appeal.                     
              Rather, claims 5 through 9 stand rejected under 35 U.S.C. § 112, second paragraph, as                    
              being indefinite.  Claims 5, 9 and 11 through 18 also stand rejected under 35 U.S.C.                     
              § 112, first paragraph (enablement).  We reverse.  In addition, we raise an issue for the                
              examiner and appellants to consider upon return of the application.                                      
                                                    DISCUSSION                                                         
              1.  Definiteness                                                                                         
                     As set forth on pages 2-3 of the Examiner's Answer, the examiner considers claims                 
              5 to 9 to be indefinite through their use of the word “homology” since “this term is                     

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