Ex parte KLOSE - Page 3




          Appeal No. 95-2441                                                          
          Application 07/987,211                                                      
               a specific gravity between about 0.3 and 2.0 and                       
          comprising:                                                                 
                    (a) a core comprising bioactive substance;                        
                    (b) a hydrophobic coating encapsulating said core in              
          a                                                                           
               quantity sufficient to essentially preclude introduction               
          of                                                                          
               bioactive substance into the rumen; and                                
                    (c) a surfactant applied to the surface of the                    
               hydrophobic coating in a quantity sufficient to ensure                 
          that                                                                        
               said particles do not float on the rumen.                              
                    26. A composition of matter comprising particles                  
               suitable for introduction of choline chloride to the                   
               post-rumen portion of the digestive system of a ruminant               
               substantially without introducing choline chloride to the              
               rumen portion of the digestive system, said particles                  
          having                                                                      
               a specific gravity between about 0.3 and 2.0 and                       
          comprising:                                                                 
                    (a) a core comprising approximately 70 percent by                 
               weight choline chloride on a cereal carrier; and                       
                    (b) a hydrophobic coating encapsulating said core in              
          a                                                                           
               quantity sufficient to essentially preclude introduction               
          of                                                                          
               choline chloride into the rumen                                        
                                     Discussion                                       
          1.   Rejections over Ghebre-Sellassie                                       
               Ghebre-Sellassie (G-S) describes (G-S, col. 1, l. 59-68):              
                    . . . a water-dispersible formulation of gemfibrozil              
               . . . in which finely divided particles of pure                        
          gemfibrozil                                                                 
               are uniformly coated with a mixture of a wax and at least              
                                          - 3 -                                       





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