Ex parte JAYASENA et al. - Page 5




            Appeal No. 1995-2611                                                                              
            Application 07/808,452                                                                            



                   required is that the amount of experimentation “must not be unduly                         
                   extensive.”  Atlas Powder Co., v. E.I. DuPont De Nemours & Co., 750 F.2d                   
                   1569, 1576, 224 USPQ 409, 413 (Fed. Cir. 1984).  The Patent and                            
                   Trademark Office Board of Appeals summarized the point well when it                        
                   stated:                                                                                    
                         The test is not merely quantitative, since a considerable                            
                         amount of experimentation is permissible, if it is merely                            
                         routine, or if the specification in question provides a                              
                         reasonable amount of guidance with respect to the direction in                       
                         which the experimentation should proceed to enable the                               
                         determination of how to practice a desired embodiment of the                         
                         invention claimed.                                                                   
                   Ex parte Jackson, 217 USPQ 804, 807 (1982).                                                
            Here, all we have is the examiner’s assertion that one skilled in the art can only make and       
            use the claimed invention throughout its scope through undue experimentation.  Clearly, the       
            fact finding needed in order to support this assertion has not been done by the examiner.         
            Accordingly, we must reverse this rejection.                                                      
                                                Obviousness                                                   
                   As stated in Pro-Mold & Tool Co. v. Great Lakes Plastics, Inc., 75 F.3d 1568, 1573,        
            37 USPQ2d 1626, 1629, (Fed. Cir. 1996) (citation omitted):                                        
                   It is well-established that before a conclusion of obviousness may be made                 
                   based on a combination of references, there must have been a reason,                       
                   suggestion, or motivation to lead an inventor to combine those references.                 
            The examiner sets forth at page 4 of the Final Rejection (Paper No. 13, April 22, 1993),          
            that the reason for combining the references was "to cleave RNA."  The examiner                   
            distanced herself from this statement in the paragraph bridging pages 9-10 stating "The           

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