Ex parte SONTHEIMER et al. - Page 5




          Appeal No. 1995-2785                                                          
          Application No. 07/576,423                                                    


                                      DISCUSSION                                        
               On consideration of the record, we shall not sustain the                 
          examiner's rejections under 35 U.S.C. § 112, first and second                 
          paragraphs.                                                                   
               Claims 17 through 19, 21 through 23, 26, and 30 stand                    
          rejected under 35 U.S.C. § 112, first paragraph, as based on a                
          specification which does not adequately teach how to make or                  
          how to use the claimed invention.  In view of its brevity, we                 
          here reproduce the entire statement of rejection from the                     
          Examiner's Answer (Paper No. 24), paragraph bridging pages 3                  
          and 4:                                                                        
               Enablement is not commensurate in scope with                             
               any $14, $18, or $22-nucleotide long region of the                       
               DNA sequence of Figure 2 as claimed in claims 17, 18                     
               and 19, respectively.  The specification as filed                        
               teaches how to use such fragments in those cases                         
               where the fragments encode epitopic portions of                          
               protein.  However, the scope of the claims is such                       
               as to include all possible DNA fragments from either                     
               the coding or the non-coding strands of the                              
               molecule, which fragments exceed a minimum stated                        
               length.  The current specification as filed does not                     
               teach how to make and use all such possible                              
               fragments.  Specifically, only a limited number of                       
               such fragments will encode epitopic regions of the                       
               Ro antigen, and applicants have failed to present                        
               teachings commensurate in scope with claims to                           
               nucleic acids which do not encode epitopic regions.                      



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