Ex parte DAVIES et al. - Page 4




          Appeal No. 95-3746                                                          
          Application 08/063,431                                                      


          selectively block the uptake of serotonin (5-HT) (claims 1-8                
          and 12-16) or dopamine (claims 9-11).  The examiner’s                       
          interpretation (answer, page 4) of the claims as being methods              
          for treating the diseases disclosed in appellants’                          
          specification, such as Parkinson’s disease, clearly is                      
          incorrect.                                                                  
               Appellants provide in vitro data in their specification                
          (Table 1, page 22) which show that the claimed methods are                  
          useful for selectively blocking the uptake of serotonin and                 
          dopamine.  The examiner argues that such methods are devoid of              
          utility absent a showing that they are inexorably linked to                 
          the treatment of a particular disease (answer, pages 7-8).                  
          This argument is not well taken because the selective blocking              
          of the uptake of serotonin and dopamine are pharmacological                 
          activities, and in the pharmaceutical arts, “practical utility              
          may be shown by adequate evidence of any pharmacological                    
          activity.”  Fujikawa v. Wattanasin, 93 F.3d 1559, 1564, 39                  
          USPQ2d 1895, 1899 (Fed. Cir. 1996).                                         
               The examiner argues that appellants have not shown that                
          their in vitro tests indicate in vivo activity (answer, page                


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