Ex parte IBRAHIM et al. - Page 5



             Appeal No. 95-4321                                                                                       
             Application 07/976,241                                                                                   


             which is missing from the disclosure of Beadle, the examiner has relied on Fiehring as                   
             disclosing the use of yeasts, such as Saccharomyces sp., to remove lactose and the                       
             cleavage products, galactose and glucose, from milk. (Answer, paragraph bridging pages                   
             5-6). Hartley is said to teach that "yeasts such as Saccharomyces cerevisiae can be useful               
             for the preparation of sugars from whey and the fermentation of ethanol from lactose.                    
             (Answer, page 6).  Barker is said to teach "a process for the production of tagatose via the             
             conversion of galactose in the presence of L-arabinose isomerase---." (Answer, page 6).                  
             The examiner then concludes (Answer, page 7):                                                            
                    It would have been obvious to modify the conventional method steps and                            
                    reaction conditions taught by the Beadle et al patent to optimize the                             
                    production of tagatose in view of the Fiehring et al (Abstract) which teaches                     
                    the conventional use of yeasts, viz., Saccharomyces sp to remove lactose                          
                    and the cleavage products, galactose- and glucose-cultures, in a process for                      
                    the preparation of milk free carbohydrates and in view of the Harley                              
                    (Abstract) which teaches that the same species of yeasts can be used for                          
                    the preparation of sugars from whey and the fermentation of ethanol from                          
                    lactose.  Also, it would have been obvious to modify the method steps and                         
                    reaction conditions taught by the Beadle et al. reference to optimize                             
                    production of the sugar tagatose in view of the Barker et al. reference which                     
                    teaches that the use of metal ions and L-arabinose isomerase enzyme                               
                    derived from microorganisms can be used in a process for production of the                        
                    sugar tagatose.                                                                                   
                    The examiner bears the initial burden of presenting a prima facie case of                         
             obviousness.  In re Oetiker, 977 F.2d 1443, 1445, 24 USPQ2d 1443, 1444                                   
             (Fed. Cir. 1992).  On the record before us, the examiner has failed to establish a prima                 
             facie case of unpatentability of the claimed subject matter.   Fiehring and Hartley do not               



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