Appeal No. 95-4491
Application No. 07/864,210
rejection of claims 1, 9, 13, 19, 21, 23-28 and 30-32, all of
the claims pending in the application. Claims 1 and 26 are 2
illustrative of the subject matter on appeal and read as
follows:
1. A method for the protection of human or animal
ophthalmic endothelial or epithelial cells subject to trauma
during surgery which comprises administering a therapeutically
effective amount of a stable, viscous, aqueous composition to
said cells during surgery, said aqueous composition consisting
essentially of a mixture of chondroitin sulfate and sodium
hyaluronate in an aqueous buffer, each of said chondroitin
sulfate and said sodium hyaluronate being contained in said
aqueous buffer in a concentration of about 0.1 to 50 wt. %,
said mixture exhibiting a synergistic viscosity which exceeds
the sum of the individual viscosities of said chondroitin
sulfate and sodium hyaluronate.
26. A stable, viscous, buffered aqueous solution which
comprises a mixture of chondroitin sulfate at a concentration
of about 0.1 to 50 wt. % and sodium hyaluronate at a
concentration of about 0.1 to 50 wt. %, said mixture
exhibiting a synergistic viscosity effect which is sufficient
to exceed the sum of the individual viscosities of said
chondroitin sulfate and said sodium hyaluronate.
The references relied upon by the examiner are:
Kawano et al. (Kawano) 3,405,120 Oct. 8, 1968
Balazs 4,141,973 Feb. 27, 1979
Pape 4,328,803 May 11, 1982
Japan Pharmaceutical Information Center (Editors), DRUGS IN
2We note that appellants have incorrectly copied claim 26
in the appendix to the appeal brief. A corrected copy of
claim 26 has been reproduced in this Decision on Appeal.
2
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