Appeal No. 1995-4623
Application No. 07/918,588
Claim 1 is representative:
1. A peptide selected from the group consisting of:
cyclo[Thr-Lys-Pro-Arg-Gly] (SEQ ID NO. 1) and pharmaceutically
acceptable salts thereof; and
cyclo[Thr-Lys-Pro-Arg-Asp] (SEQ ID NO. 2) and pharmaceutically
acceptable salts thereof.
The references relied on by the examiner are:
Chipens et al. (Chipens II)4,434,095 Feb. 28, 1984
Hahn 4,816,449 Mar. 28, 1989
Stabinsky, Y., et al. (Stabinsky), "THE PHAGOCYTOSIS STIMULATING
PEPTIDE TUFTSIN: FURTHER LOOK INTO STRUCTURE-FUNCTION
RELATIONSHIPS", Molecular & Cellular Biochemistry, Vol. 30, No. 3, pp.
165-170 (1980).
Chipens, G.I. (Chipens I), "ELONGATED AND CYCLIC ANALOGUES OF
TUFTSIN AND RIGIN", Peptides, Proceedings of European Peptides
Symposium, 16th, pp. 445-450 (1981).
Siemion, I.Z., et al. (Siemion), "Tuftsin analogs and their biological activity",
Molecular and Cellular Biochemistry Vol. 41, pp. 99-111 (1981).
Nikiforovich, G.V., "Biologically active conformation of tuftsin", International
Journal of Peptide Protein Research, Vol. 23, pp. 271-275 (1984).
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