Appeal No. 95-4700
Application 07/837,668
Charbit et al. (Charbit), “Presentation of Two Epitopes of the preS2 Region of Hepatitis B
Virus on Live Recombinant Bacteria,” The Journal of Immunology,” Vol. 139, No. 5, pp.
1658-64 (1987).
Kuwajima et al. (Kuwajima), “Presentation of an Antigenic Determinant From Hen Egg-
White Lysozyme on the Flagellar Filament of Escherichia Coli,” Bio/Technology, Vol. 6, pp.
1080-89 (1988).
Charbit et al. (Charbit), “Expression of a Poliovirus Neutralization Epitope at the Surface of
Recombinant Bacterial: First Immunization Results,” Ann. Inst.Pasteur/Microbiol., Vol. 139,
pp. 45-58 (1988).
Ellis et al. (Ellis) PCT WO 86/00911 Feb. 13, 1986
Claims 1 through 3, 6, 7, 21, 37, 38, 72 and 73 stand rejected under 35 U.S.C.
§ 102(e) as anticipated by Asaka. Claims 4 and 5 stand rejected under 35 U.S.C.
103. As evidence of obviousness, the examiner relies upon Asaka, Macnab and Wei.
Claims 8 through 11 stand rejected under 35 U.S.C. § 103. As evidence of obviousness,
the examiner relies upon Asaka, Eichinger or Ellis. Claims 56 through 58 and 61 stand
rejected under 35 U.S.C. § 103. As evidence of obviousness, the examiner relies upon
Asaka, Charbit 1987 and Charbit 1988. Claims 59 and 60 stand rejected under 35 U.S.C.
§ 103. As evidence of obviousness, the examiner relies upon Asaka, in view of Charbit
1987 or 1988, Macnab and Wei. Claims 39 through 41 stand rejected under 35 U.S.C. §
103. As evidence of obviousness, the examiner relies upon Asaka in view of Charbit 1987
or 1988, Macnab, Wei and Dougan. In addition, claims 1 through 11, 21, 37 through 41,
56 through 61, 72 and 73 stand rejected under
35 U.S.C. § 112, second paragraph, as being indefinite.
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