Ex parte SPECK - Page 8




                     Appeal No. 95-5133                                                                                                                                                
                     Application 08/135,523                                                                                                                                            


                     the prima facie case of unpatentability over Merck and Remington's.  See In re Papesch, 315 F.2d                                                                  

                     381, 386, 137 USPQ 43, 47 (CCPA 1963).                                                                                                                            











                                The rejection of claims 1, 5-8, and 12 under 35 U.S.C. § 103 is reversed.                                                                              

                                                                               Other Matters:                                                                                          

                                Should further prosecution take place before the examiner, we urge the examiner to step back                                                           
                     and consider, anew,  the disclosure of French Patent 2,255,883 .  While the invention described in the3                                                                       

                     French patent is to a combination of clofibric acid and at least one substance with vitamin B activity, it                                                        
                                                                                                                                                         6                             
                     would appear that the patent also discloses that “substances with B  action . . . . had a good                                                                    
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                     hypocholesterolemic . . . action.” Such a disclosure might reasonaly suggest the use of this compound in                                                          

                     the treatment and prevention of atherosclerosis and/or hyperlipidemia.  The examine should note                                                                   

                     particularly pages 2 and 3 of the translation.  See also Table 1 where the effect of vitamin B  per se,                                                           
                                                                                                                                                        6                              
                     i.e., not co-administered with clofibric acid, on levels of  serum cholesterol and serum lipids is                                                                

                                3A translation of this reference has been prepared for the PTO by Diplomatic Language                                                                  
                     Services, Inc., in March 1999, a copy of which is attached to this decision.                                                                                      
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