Ex parte HEINE et al. - Page 5




          Appeal No. 96-0676                                                          
          Application 07/963,165                                                      


          appellants that the aforementioned rejections are not well                  
          founded.  Accordingly, we do not sustain these rejections.                  
                  Rejection under 35 U.S.C. § 112, first paragraph                    
               Regarding enablement, a predecessor of our appellate                   
          reviewing court stated in In re Marzocchi, 439 F.2d 220, 223-               
          24, 169 USPQ 367, 369-70 (CCPA 1971):                                       
                    [A] specification disclosure which contains a                     
               teaching of the manner and process of making and                       
               using the invention in terms which correspond in                       
               scope to those used in describing and defining the                     
               subject matter sought to be patented must be taken                     
               as in compliance with the enabling requirement of                      
               the first paragraph of § 112 unless there is reason                    
               to doubt the objective truth of the statements                         
               contained therein which must be relied on for                          
               enabling support. . . .                                                
                                       . . . .                                        
               . . . it is incumbent upon the Patent Office,                          
               whenever a rejection on this basis is made, to                         
               explain why it doubts the truth or accuracy of any                     
               statement in a supporting disclosure and to back up                    
               assertions of its own with acceptable evidence or                      
               reasoning which is inconsistent with the contested                     
               statement.  Otherwise, there would be no need for                      
               the applicant to go to the trouble and expense of                      
               supporting his presumptively accurate disclosure.                      
               The examiner argues that compounds which bind to each 5HT1             
          subtype of receptor must meet specific structural requirements              
          in order to bind to the receptor (answer, page 4).  In support              

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