Ex parte HEINE et al. - Page 6




          Appeal No. 96-0676                                                          
          Application 07/963,165                                                      


          of this argument, the examiner relies upon Glennon (page 2),                
          which discloses that some compounds have a higher selectivity               
          and/or affinity for one 5-HT site subtype than for another                  
          subtype.  In the examiner’s view, appellants’ specification                 
          (page 13) enables binding of appellants’ compounds only to 5-               
          HT  sites, and not broadly to 5-HT  sites (answer, page 4).1A                            1                                         
               Appellants’ specification states (page 11, lines 13-16)                
          that the claimed compounds have particularly high affinity for              
          5-HT  receptors, and provides guidance as to dosage amounts of              
              1                                                                       
          the compounds (page 15, lines 7-12).  This disclosure                       
          corresponds in scope to the recitation in appellants’ claims                
          6, 8 and 10.  The examiner has not explained, and we do not                 
          find, why Glennon would have indicated to one of ordinary                   
          skill in the art that appellants’ claimed compound would not                
          be effective for binding to 5-HT  receptors as required by                  
                                          1                                           
          appellants’ claims 6, 8 and 10.  Thus, the examiner has not                 
          carried her burden of providing evidence or technical                       
          reasoning which shows that the statements                                   
          in appellants’ specification regarding how to use their                     
          claimed compounds are incorrect.  Merely referring to an                    


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