Ex parte COLE et al. - Page 2




          Appeal No. 99-0624                                                          
          Application 07/749,482                                                      


               This is an appeal from the examiner’s final rejection of               
          claims 112-118, 120-122 and 128-131, which are all of the                   
          claims remaining in the application.                                        
                                    THE INVENTION                                     
               Appellants’ claimed invention is directed toward                       
          pharmaceutical compositions which are useful for $-lactamase                
          inhibition in humans and animals and which include clavulanic               
          acid or a pharmaceutically acceptable salt thereof, in                      
          combination with a pharmaceutically acceptable carrier or in                
          pharmaceutically acceptable form.  Claims 112 and 128 are                   
          illustrative and read as follows:                                           
               112.  A pharmaceutical composition useful for effecting                
          $-lactamase inhibition in humans and animals which comprises a              
          $-lactamase inhibitory amount of a pharmaceutically                         
          acceptable salt of clavulanic acid, in combination with a                   
          pharmaceutically acceptable carrier.                                        

               128.  A $-lactamase inhibitory pharmaceutical composition              
          comprising solid clavulanic acid or a pharmaceutically                      
          acceptable salt thereof in a $-lactamase inhibitory amount in               
          pharmaceutically acceptable form.                                           
                                                                                     
                                    THE REFERENCE                                     
          Eli Lilly & Co. (Lilly)            1,315,177      Apr.                      
          26, 1973                                                                    

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