Ex parte COLE et al. - Page 4




          Appeal No. 99-0624                                                          
          Application 07/749,482                                                      


          with a pharmaceutically acceptable carrier, or be in a                      
          pharmaceutically acceptable form (claim 128), and it is not                 
          apparent where Lilly discloses each of these limitations.  We               
          therefore do not sustain the rejection under 35 U.S.C.                      
          § 102(b).                                                                   




                           Rejection under 35 U.S.C. § 103                            
               The examiner argues that since Lilly’s “other antibiotic               
          substances” have been found to include clavulanates, it would               
          have been prima facie obvious to one of ordinary skill in the               
          art to purify the clavulanates and use them in conventional                 
          forms for administration (answer, pages 24-25).  This argument              
          is not well taken because the examiner has not established                  
          that it was known in the art that Lilly’s “other antibiotic                 
          substances” include clavulanic acid or clavulanates.  The                   
          examiner argues that Lilly’s characterization of the                        
          antibiotic substances as such indicates that the substances                 
          were separated and tested sufficiently to determine that they               
          are antibiotics and include clavulanic acid and clavulanates                


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