MORRISON et al. V. MANNHEIMER et al. - Page 20




          Interference No. 103,197                                                      


          the target vessel or a vessel which leads to the target                       
          cardiac chamber, e.g., a femoral artery or jugular vein.                      
               Kapany also describes using a fiber optics catheter                      
          inside a hypodermic needle to measure oxygen in peripheral                    
          vessels:34                                                                    
                    This remote spectrophotometer using fiber optics has                
               also been used for the measurement of dye concentration.                 
               Since the return signal on the instrument is a direct                    
               function of the flow velocity, it should be possible,                    
               with appropriate calibrations, to deduce the flow                        
               velocity.  With appropriate designs of catheter probes,                  
               it is possible to use this technique for long-term                       
               monitoring of oxygen saturation within peripheral                        
               vessels.  Figure 7.26a shows a photograph of a catheter                  
               that has a hypodermic needle at the tip.                                 
          Kapany’s only discussion of measuring the oxygen saturation of                
          blood in tissue (as opposed to an artery, vein, or cardiac                    
          chamber) is the following discussion of a non-invasive, clip-                 
          on  oximeter probe:                                                           
               Figure 7.26b shows another catheter design for precise                   
               ear oximetry.  In this case, the fiber bundle is divided                 
               in two parts to provide sharp curves to the bundles so                   
               that one end may be placed in front of the ear lobe and                  
               the other in back of the ear lobe.  [Page 197, lines 5-                  
               8].                                                                      
          Section 3 concludes with the following paragraph:                             
                    The in vivo oximeter has been discussed at some                     

            Paragraph bridging pages 195 and 197.34                                                                       
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