Interference No. 103,605
Ser Ser Ser Arg
Thr Pro Ser Asp Lys Pro Val Ala His Val
Val Ala Asn Pro Gln Ala Glu Gly Gln Leu
Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu
Leu Ala Asn Gly Val Glu Leu Arg Asp Asn
Gln Leu Val Val Pro Ser Glu Gly Leu Tyr
Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly
Gln Gly Cys Pro Ser Thr His Val Leu Leu
Thr His Thr Ile Ser Arg Ile Ala Val Ser
Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala
Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro
Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu
Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu
Glu Lys Gly Asp Arg Leu Ser Ala Glu Ile
Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu
Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala
Leu;
or
a human tumor necrosis factor-alpha polypeptide which
a) migrates as a single band on a SDS-PAGE gel to a
molecular weight of about 17,000;
b) is purified to a degree sufficient for sequencing by
sequential Edman degradation;
c) has an isoelectric point of about 5.3;
d) is susceptible to trypsin hydrolysis at more than one
site in the polypeptide;
e) under physiological conditions, spontaneously aggregates
into multimers;
f) is unglycosylated; and
g) is capable of the preferential destruction or growth
inhibition of tumor cells when compared to normal cells under the
same conditions.
3
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Last modified: November 3, 2007