CHILD et al. V. KOLAR et al. - Page 12




                 Interference No. 102,408                                                                                                               


                 no. 1 at Lederle  by (CR355):14                                                                                                        
                          [T]reating 945 mg. of 3,3-oxetainedimethanamine in                                                                            
                          40 cc of water with 820 mg. of sodium acetate and                                                                             
                          2.075 g of potassium tetrachloroplatinate.  The                                                                               
                          mixture was stirred for three hours and filtered.                                                                             
                          The filtered crystals weighed 0.37g; mp 262 dec. and                                                                          
                          were labeled “A”.  The filtrate was allowed to stand                                                                          
                          overnight and then the resulting solid was collected                                                                          
                          giving 440 mg of product as bright yellow crystals                                                                            
                          melting at 270-272E which was labeled “B”.                                                                                    
                 Compare CR365 (product labeled "A" described as beige solid                                                                            
                 having melting point of 262E; product "B" described as bright                                                                          
                 yellow crystals having melting point of 270-273E).  Products                                                                           
                 labeled “C”, “D” and “E” also appear to have been prepared                                                                             
                 during the process (CR365).                                                                                                            
                          Various notations have been used throughout the record to                                                                     
                 identify products which appear to be described on page 47 of                                                                           
                 notebook 12459B.  For example, a request for infrared analysis                                                                         
                 prepared by Ralph G. Child uses the notation "sample no.                                                                               
                 12459B-47B" to identify one such compound.   See CR356,  4;               15                                                          


                          14American Cyanamid Company, Lederle Laboratories                                                                             
                 Division, Pearl River, New York, USA (hereinafter "Lederle").                                                                          
                          15Presumably, the notation "12459B-47B" is intended to                                                                        
                 identify the product labeled "B" on page 47 of Child's                                                                                 
                 notebook 12459B, the preparation of which is described                                                                                 
                 therein.  Compare CR365 (product "B" described as "bright                                                                              
                 yellow crystals wt=0.44 mp 270-273E") with CR366                                                                                       
                 ("[Stru]cture, Color and State [:]  yellow crystals [;] BP or                                                                          
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