Interference No. 103378
APPENDIX
Count 3
A compound having the structure
or a pharmaceutically acceptable salt thereof wherein:
R4 is hydrogen, aroyl, C1 to C6 alkoyl, a pharmaceutically acceptable
cation or metabolically cleavable group;
R1 is hydrogen, C1 to C12 alkyl, C2 to C4 alkenyl, C3 to C8 cycloalkyl,
alkylthioalkyl, alkoxyalkyl or -NR2R3;
R2 and R3 are each independently hydrogen, hydroxy, C1 to C6 alkyl, C1
to C6 hydroxyalkyl, C2 to C8 alkanoyl, alkoxyalkyl in which the alkoxy portion and
the alkyl portion each contain, independently, from 1 to 6 carbon atoms, aryl or
aryl substituted with one or more substituents selected from the group consisting
of halo, nitro, cyano, C1 to C12 alkyl, C1 to C12 alkoxy, C1 to C12
halosubstituted alkyl, C1 to C12 hydroxysubstituted alkyl, C1 to C12
alkoxycarbonyl, aminocarbonyl, C1 to C12 alkylaminocarbonyl, di C1 to C12
alkylaminocarbonyl and C1 to C12 alkylsulfonyl, provided that R2 and R3 are not
both hydroxy;
A is C1 to C6 alkylene or C2 to C6 alkenylene;
B is independently, halo, nitro, cyano, -SH, hydroxy, C1 to C6 alkyl, C1 to
C6 alkoxy, C1 to C6 halosubstituted alkyl, C1 to C6 thioalkyl, C2 to C6 alkenyl,
C1 to C12 aminocarbonyl, C1 to C6 alkylaminocarbonyl, di C1 to C6
alkylaminocarbonyl or C2 to C12 alkoxyalkyl;
Ar is
a) C5 to C20 alkyl
b) C3 to C8 cycloalkyl
c) optionally substituted carbocyclic aryl
d) optionally substituted carbocyclic
14
Page: Previous 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 Next
Last modified: November 3, 2007