Interference No. 103,203
determined that (a) full length, mature tissue factor consisted of 263 amino
acids, (b) the sequence of a nucleotide molecule encoding the complete
amino acid sequence of full length, mature tissue factor from amino acid 1 to
amino acid 263, and (c) the complete amino acid sequence for full length,
mature tissue factor from amino acid 1 to amino acid 263. NR 111-113;
NRE 277; NR 1982-1983; NR 173-174; NR 2861-2862; NR 173-174. On
February 3, 1987, Dr. Yale Nemerson of Nemerson sent a letter reflecting
that, by that date, Nemerson had determined the entire coding sequence of
the human tissue factor clone. NR 2873, ¶18; 3295. Nemerson had
obtained sufficient information regarding the full length tissue factor clone to
isolate a DNA segment of not more than 1133 nucleotides encoding full
length, mature human tissue factor from amino acid 1 to amino acid 263.
See NR 1952, l. 6 to 1957, l. 3; NRE 282.
44. On February 19, 1987, Dr. Ronald Bach of Nemerson listed in his
handwriting the complete amino acid sequence of full length, mature human
tissue factor from amino acid 1 to amino acid 263 (NR 131-135; NRE 271),
from which a nucleotide sequence encoding full length, mature
human tissue factor from amino acid 1 to amino acid 263 could be derived.
NR 135.
45. On February 23, 1987, Dr. Ronald Bach of Nemerson printed a
computer listing of the complete amino acid sequence for full length, mature
human tissue factor from amino acid 1 to amino acid 263 (NR 136-138;
NRE 279), from which a nucleotide sequence encoding full length, mature
human tissue factor from amino acid 1 to amino acid 263 can be derived
(NR 131-1350 [sic, 135?]; 3750 [sic]), and which demonstrates the structure
of the protein encoded by the clone isolated by Nemerson.
49. On March 24, 1987, Dr. Eleanor Spicer of Nemerson printed a
computer listing of the nucleotide sequence of the 8 10, 3 clone isolated in
October 1986 (NFB 13) which encodes full length, mature human tissue
factor protein from amino acid 1 to amino acid 263, and the complete amino
acid sequence for full length, mature human tissue factor protein from amino
acid 1 to amino acid 263 which is encoded by the clone. NR 48-49; 1834-
1835; 3782-3786; NRE 93.
The Edgington et al. position with respect to Nemerson et al.
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