Interference No. 103,203
of nucleotide sequence compiled from human tissue factor subclones, encoding more than
80% of the complete amino acid sequence of mature human tissue factor
protein, including the amino terminal end of mature human tissue factor protein (amino
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acids 1-244) (NR 99-100; 96; NRE 276).” Nemerson Brief, p. 19, para. 39.
(2) Dr. Bach is said to have “prepared a document aligning actual tissue factor
amino acid sequence with tissue factor-encoding nucleotide sequence, including the
nucleotide sequence encoding mature human tissue factor from amino acid 1 to amino
acid 217 [from the January 23, 1987 computer listing]. NR 39-43; 93; 91; 96-98; 1833-
834; 3748-750; NRE 83; 275.” Nemerson Brief, p. 19, para. 39.
(3) On pp. 20-22 of their brief, Nemerson et al. state the following:
41. On February 3, 1987, Nemerson printed computer listings of
nucleotide sequence, compiled from tissue factor subclones encompassing
the entire coding region of the full length, mature tissue factor protein with
minor uncertainties. NR 3822-3825; 116-119; NRE 100; 278.
42. By February 3, 1987, Dr. Ronald Bach of Nemerson had
prepared a handwritten nucleotide sequence encoding the complete amino
acid sequence for full length, mature tissue factor from amino acid 1 to
amino acid 263 and the complete amino acid sequence for full length,
mature tissue factor from amino acid 1 to amino acid 263. See NR 101-111;
156; NRE 277.
43. On February 3 and 4, 1987, Dr. Ronald Bach of Nemerson
communicated to others working on the tissue factor project that he had
10The Nemerson et al., Edgington et al. and Lawn et al. record will be referred to as NR, ER and
LR, respectively, followed by the appropriate number. Similarly, the Nemerson et al., Edgington et al. and
Lawn et al. exhibits will be referred to as NRE, ERE and LRE, followed by the appropriate number.
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