Ex parte LEANDER et al. - Page 7

          Appeal No. 1996-0682                                                        
          Application 08/127,121                                                      

          the prior art Leander patent).  However, we agree with the                  
          examiner that it would have been prima facie obvious to                     
          utilize the prior art “standard carrier,” fractionated coconut              
          oil, as a carrier material component for the podophyllotoxin                
          creams described in the Leander patent, invited by Leander’s                
          statement that all useful prior art carrier materials may be                
          utilized by one skilled in the art to prepare the prior art                 
          creams especially those which do not react unfavorably with                 
          the active compound or exert some unsuitable effect when                    
          combined with the active compound.                                          
               Moreover, notwithstanding appellants’ arguments in the                 
          brief, we agree with the examiner that Makino constitutes                   
          additional evidence of the obviousness of successfully using                
          fractionated coconut oil in a podophyllotoxin cream                         
          composition.  In this regard, Makino teaches a cream                        
          preparation which may include, inter alia, podophyllotoxin as               
          an active ingredient and may include the “normally used”                    
          fractionated coconut oil as an oil component for a body                     
          temperature soluble solid preparation.  See Makino at column                
          9, line 44; column 11; lines 49-68.  Thus, the examiner                     
          persuasively argues that it would have been obvious to a                    

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