Ex parte FONG et al. - Page 6





              Appeal No. 1996-1204                                                                                     
              Application No. 08/090,369                                                                               


              been obvious to use the methodology of Hopkins and Gerard to isolate, identify and                       
              characterize a protein not demonstrated to be known at the time of the invention.  The                   
              examiner's reliance (Answer, page 14) on the concluding statements of both Hopkins and                   
              Gerard concerning further studies relating to the neurokinin receptor genes is too general               
              in nature reasonably to point those of ordinary skill in this art toward the isolation and               
              characterization of the claimed human NK-3 receptor and DNA encoding the receptor,                       
              when read in context of the teaching of the articles as a whole.  On these facts, the                    
              examiner has failed to establish a prima facie case of unpatentability as to the claimed                 
              subject matter.                                                                                          
                     Where the examiner fails to establish a prima facie case, the rejection is improper               
              and will be overturned.  In re Fine, 837 F.2d 1071, 1074, 5 USPQ2d 1596, 1598 (Fed.                      
              Cir.1988).  Therefore the rejection of claim 25-28 and 30 under 35 U.S.C. § 103 is                       
              reversed.                                                                                                
                     In separately rejecting claim 29 under 35 U.S.C. § 103 the examiner has relied on                 
              Fraser in addition to Shigemoto, Hopkins and Gerard.  However, Fraser does not provide                   
              that which we have determined to be missing in the previously discussed rejection.                       
              Therefore, this rejection is also reversed.                                                              




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