Appeal No. 1996-1934
Application 07/884,218
Claims 1, 22 and 23 are illustrative of the subject matter on appeal and are
reproduced below:
1. A method for introduction of medicaments to and retaining said
medicament in the peritoneal cavity of a mammal undergoing surgery which
comprises providing to the peritoneal cavity a solution of a medicament to combat
interperitoneal infection and a hyaluronic acid compound selected from hyaluronic
acid and water-soluble salts thereof in a sterile isotonic, flowable, pharmaceutically
acceptable media in which the hyaluronic acid compound is present in a
concentration of at least about 0.4% by weight based on the weight of the solution,
said solution having a viscosity at 25"C of from about 500 to about 10,000
centipoise, said hyaluronic acid compound serving to retain said medicament in the
peritoneal cavity.
22. A method for combating infections of the peritoneal cavity which
comprises providing to the peritoneal cavity of a mammal undergoing surgery, a
solution of a medicament and an hyaluronic acid compound selected from
hyaluronic acid and water-soluble salts thereof in a sterile, isotonic, flowable
pharmaceutically acceptable media in which the hyaluronic acid compound is
present in a concentration of at least about 0.4% by weight based on the weight of
the solution, said solution having a viscosity at 25"C of from about 500 to about
10,000 centipoise, said hyaluronic acid compound acting to retain the inroduced
medicament in the peritoneal cavity, the amount of solution applied being in an
amount sufficient to at least coat traumatized tissue and up to an amount sufficient
to coat the peritoneal cavity, said solution being applied to the peritoneal cavity
during the period from beginning of surgery up to closure at conclusion of surgery.
23. A method as claimed in claim 22 in which the solution is applied as a
single application at closing of the peritoneal cavity at the end of the operative
procedure.
The references relied upon by the examiner are:
Della Valle et al. 4,736,024 Apr. 5, 1988
(Della Valle)
Goldberg et al. 5,080,893 Jan. 14, 1992
(Goldberg)
GROUND OF REJECTION
2
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