Ex parte DI ZEREGA - Page 4


                    Appeal No. 1996-1934                                                                                                  
                    Application 07/884,218                                                                                                

                    THE REJECTIONS UNDER 35 U.S.C. § 103:                                                                                 
                    Claims 1-14, 16, 18, 19, 22 and 24-31:                                                                                
                            At page 4 of the Answer, the examiner states:                                                                 
                                            Goldberg et al disclose introduction of hyaluronic                                            
                                    acid into peritoneal cavity (see, for example, column 5,                                              
                                    lines 63-68 and column 6, lines 13-15) but do not                                                     
                                    disclose introduction of a combination of hyaluronic                                                  
                                    acid and a medicament into peritoneal cavity.                                                         
                                    However, since della Valle et al. disclose hyaluronic                                                 
                                    acid to be a conventional carrier for various                                                         
                                    medicaments, including antibiotic clindomycin, a person                                               
                                    having ordinary skill in the art at the time the instant                                              
                                    invention was made would have been motivated to                                                       
                                    introduce into peritoneal cavity a solution of hyaluronic                                             
                                    acid and a medicament in order to prevent surgical                                                    
                                    adhesions and to combat intraperitoneal infection.                                                    
                            Appellant argues at page 10 of the Brief that in order:                                                       
                                            To determine whether the Examiner’s position                                                  
                                    has merit one must determine how far the applied art                                                  
                                    went and the standards for surgical procedure to                                                      
                                    determine whether the surgeon would leave a solution                                                  
                                    of hyaluronic acid and a medicament in the peritoneal                                                 
                                    cavity following surgery to combat bacterial infections                                               
                                    on closure.                                                                                           
                    Appellant emphasizes the idea of leaving a solution of hyaluronic acid and a                                          
                    medicament in the peritoneal cavity, at page 12 of the Brief, citing the di Zerega                                    
                    Declaration (Paper No.13, received September 28, 1992), and stating “standard                                         
                    operating procedure was to remove all adjuvant substances and aspirate all excess                                     
                    irrigant at closure.”   Appellant further emphasized this position in the Reply Brief,                                
                    bridging paragraph of pages 3-4, “the specification makes clear that the hyaluronic                                   




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