Ex Parte BERGMEYER et al - Page 8




                Appeal No. 1996-2442                                                                                                         
                Application 08/062,021                                                                                                       
                modified would not have made the modification obvious unless the prior art suggested                                         
                the desirability of the modification.  In re Gordon, 733 F.2d 900, 902, 221 USPQ 1125,                                       
                1127 (Fed. Cir. 1984).  Here we find no reason stemming from the prior art which would                                       
                have led a person having ordinary skill to the claimed invention.  In our judgment, the                                      
                only reason or suggestion to combine the references in the manner proposed by the                                            
                examiner comes from appellants’ specification.                                                                               
                        On this record, we are constrained to reverse Rejections I and II.                                                   


                Rejection III                                                                                                                
                        Claim 38, directed to an oligonucleotide primer of defined sequence, stands                                          
                rejected under 35 U.S.C. § 103 as unpatentable over Brytting and Gibbs.  Both                                                
                references are discussed above.                                                                                              
                        Again, the examiner has made no attempt to address the requirement for a                                             
                primer with a specific sequence, concluding simply that “[i]t would have been prima                                          
                facie obvious to one of ordinary skill in the art at the time the instant invention was                                      
                made to arrive at the oligonucleotides directed against hCMV.  [Brytting] provides the                                       
                motivation for making primers directed against hCMV, . . . [Gibbs] provides the teaching                                     
                and rationale to design primers which are conformed to the narrow range of melting                                           
                temperature.”  Examiner’s Answer, page 11.                                                                                   
                        Again, we find no reason stemming from the prior art which would have led a                                          
                person having ordinary skill to the specific primers claimed.  Even if the examiner had                                      

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