Appeal No. 1996-2537
Application No. 08/102,654
page 2, lines 3-6, and 23-24. This compound selectively
inhibits the
biosynthesis of glycolipids “without effect either on the
maturation of N-linked oligosacchrides or lysosomal
glucocerebrosidase.” Specification, page 2, line 29, through
page 3, line 2.
B. Legler discloses N-heptyl-deoxygalactonojirimycin (N-
heptyl DGJ)(page 122, lines 5-6, page 127, lines 25-30, and
Table 1 at page 122). According to Legler, this compound
shows inhibition of $-D-galactosidase from E.coli and $-D-
glucosidase from almonds. See Table 1. However, Legler does
not disclose N-butyl DGJ.
C. Getman describes 1,4-dideoxy-4-fluoronojirimycin
compounds, represented by chemical formula at col. 1, line 54,
through col. 2, line 1. Getman discloses that the R group
attached to the nitrogen-ring-atom represents H or alkyl
radicals having from 1 to about 10 carbon atoms. According to
3
Page: Previous 1 2 3 4 5 6 7 8 9 10 Next
Last modified: November 3, 2007