Appeal No. 1996-2537
Application No. 08/102,654
Getman, these compounds manifest glycosidase inhibition
activity. Getman illustrates the glycosidase inhibition
activity of 1,4-dideoxy-4-fluoronojirimycin and N-butyl-1,4-
dideoxy-4-fluoronojirimycin (Table 1 at col. 14, and the
accompanying text). Getman
discloses that “[i]t is contemplated that other N-derivatives
will also manifest glycosidase inhibition activity” (col. 12,
lines 61-66).
D. The examiner concludes that a person having ordinary
skill in the art at the time the invention was made would have
found it obvious to vary the length of the alkyl chain
attached to the nitrogen-ring-atom of Legler's DGJ compound
with the expectation that the resulting compounds would be
useful in binding $-D-galactosidase from E.coli and $-D-
glucosidase from almonds. Answer, page 2, lines 18-23.
E. We agree with the examiner’s prima facie case of
obviousness. Legler’s N-heptyl-DGJ and the 1,4-dideoxy-4-
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