Ex parte DE VRIES et al. - Page 2




              Appeal No. 1996-3797                                                                                        
              Application No. 08/070,162                                                                                  


                     The references relied upon by the examiner are:                                                      
              Hall et al. (Hall), “Expression and Regulation of Escherichia coli lacZ Ghene Fusions in                    
              Mammalian Cells,” The Journal of Molecular and Applied Genetics, Vol. 2, pp 101-109                         
              (1983).                                                                                                     
              Mills et al. (Mills), “Sequences of Human Immunoglobulin Switch Regions: Implications for                   
              Recombination and Transcription,” Nucleic Acids Research, Vol. 18, pp 7305-7316,                            
              (1990).                                                                                                     
              Sambrook et al. (Sambrook), Molecular Cloning - A Laboratory Manual, Cold Spring                            
              Harbor Laboratory Press, 2nd Edition, Chapter 16, pp 16.41-16.46 and 16.57-16.58                            
              (1989)                                                                                                      
              Suter et al. (Suter), “Expression of Human Lymphocyte Ige Receptor (Fc RII/CD23),” The                      
                                                                                           E                              
              Journal of Immunology, Vol. 143, pp 3087-3092 (1989).                                                       
              Rothman et al. (Rothman), “Identification of a Conserved Lipopolysaccharide-Plus                            
              Interleukin -4- Responsive Element Located at the Promoter of Germ Line 0 Transcripts,”                     
              Molecular and Cellular Biology, Vol. 11, pp 5551-5561 (1991).                                               
              Takai et al. (Takai), “DNA Transfection of Mouse Lymphoid Cells by the Combination of                       
              DEAE-dextran-mediated DNA uptake and osmotic shock procedure,” Biochimica et                                
              Biophysicas Acta. Vol. 1048, pp 105-109 (1990).                                                             


                                                Grounds of Rejection                                                      

                     Claims 1-5 stand rejected under 35 U.S.C. § 103.  As evidence of                                     
              obviousness, the examiner relies upon Suter, Sambrook, and Takai.                                           
                     Claims 6-9 stand rejected under 35 U.S.C. § 103.  As evidence of                                     
              obviousness, the examiner relies upon Suter, Sambrook, Takai and Hall.                                      




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