Ex parte DE VRIES et al. - Page 7




              Appeal No. 1996-3797                                                                                        
              Application No. 08/070,162                                                                                  


              must be some reason, suggestion, or motivation found in the prior art whereby a person of                   
              ordinary skill in the field of the invention would make the substitutions required.  That                   
              knowledge cannot come  from the applicants' disclosure of the invention itself.   Diversitech               
              Corp. v. Century Steps, Inc.,  850 F.2d 675, 678-79,  7 USPQ2d 1315, 1318 (Fed. Cir.                        
              1988); In re Geiger, 815 F.2d 686, 688, 2 USPQ2d 1276, 1278 (Fed. Cir. 1987);                               
              Interconnect Planning Corp. v. Feil, 774 F.2d 1132, 1143,  227 USPQ 543, 551 (Fed. Cir.                     
              1985).  On the record before us, we find no reasonable suggestion for combining the                         
              teachings of the references relied upon by the examiner with Suter in a manner which                        
              would have reasonably led one of ordinary skill in this art to arrive at the claimed invention.             
              The initial burden of presenting a prima facie case of obviousness rests on the examiner.                   
              In re Oetiker, 977 F.2d 1443, 1445, 24 USPQ2d 1443, 1444  (Fed. Cir. 1992).  On these                       
              circumstances, we are constrained to reach the conclusion that the examiner has failed to                   
              provide the evidence necessary to support a prima facie case of obviousness as to the                       
              claimed cell line.  Where the examiner fails to establish a prima facie case, the rejection is              
              improper and will be overturned.  In re Fine, 837 F.2d 1071, 1074, 5 USPQ2d 1596, 1598                      
              (Fed. Cir.1988).  Therefore, the rejections of claims 1-9 under 35 U.S.C. § 103 are                         
              reversed.                                                                                                   
                                                     Other issues                                                         




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