Ex parte DE VRIES et al. - Page 3



              Appeal No. 1996-3797                                                                                        
              Application No. 08/070,162                                                                                  


                     Claims 6 and 8 stand rejected under 35 U.S.C. § 103.  As evidence of                                 
              obviousness, the examiner relies upon Suter, Sambrook, Takai, and Rothman.                                  
                     Claims 1-3, 5, 6, and 8 stand rejected under 35 U.S.C. § 103.  As evidence of                        
              obviousness, the examiner relies upon Suter, Mills, and Rothman.                                            
                     Claims 6 and 8 stand rejected under 35 U.S.C. § 103.  As evidence of                                 
              obviousness, the examiner relies upon Suter, Mills, Rothman, Sambrook and Hall.                             
                     We reverse.                                                                                          
                                                      Background                                                          

                     The applicants describe the presently claimed invention at pages 5-6 of the                          
              specification as relating to human cell lines cloned from a cell which have been stably                     
              transformed by a recombinant vector comprising a reporter gene operatively linked to a                      
              promoter comprising a human IL-4-responsive element. The stable transformed cell line is                    
              stated to be useful in detecting human IL-4 agonists and antagonists.  Applicants explain                   
              that contacting the cell line with a sample containing an IL-4 agonist or an antagonist in the              
              presence of IL-4 results in expression or reduced expression of the reporter gene.                          
                                                      Discussion                                                          

                                         The rejections under 35 U.S.C. § 103                                             
                     In reaching our decision in this appeal, we have given careful consideration to the                  
              appellants' specification and claims and to the respective positions articulated by the                     
              appellants and the examiner.  We make reference to the examiner's answer (Paper No.                         


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