Appeal No. 1997-0094
Application No. 08/188,232
Claims 1 and 4 are illustrative:
1. A compound of the formula:
X-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Z (I)
wherein X is an acetyl or pyroglutamyl group and
Z is -NH ,
2
-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-Pro-NH ,
2
-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-Gly-NH , or
2
-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn
with the proviso that when X is a pyroglutamyl group, Z is -Lys-Glu-Lys-Lys-
Glu-Val-Val-Glu-Glu-Ala-Glu-Asn, and when X is an acetyl group, Z is other
than -Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn.
4. The compound of claim 1 wherein X is an acetyl group and Z is -
Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-Gly-NH (SEQ ID NO: 3).
2
The prior art references of record relied on by the examiner are:
Haritos et al. (Haritos), "Prothymosin ": Isolation and properties of the major
immunoreactive form of thymosin " in rat thymus," Proceedings of the National Academy
1
of Sciences, USA, Vol. 81, pp. 1008-1011 (February 1984).
Zatz et al. (Zatz), "Thymosins, Lymphokines, and the Immunology of Aging," Gerontology,
Vol. 31, pp. 263-277 (1985).
Abiko et al. (Abiko II), "Synthesis and Immunological Effect of Deacetyl-thymosin " on
11
Low E-Rosette-Forming Cells of a Rheumatoid Arthritis Patient," Chemical &
Pharmaceutical Bulletin, Vol. 22, No. 12, pp. 5419-5427 (December 1985).
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