Ex parte LUDWIG et al. - Page 4




              Appeal No. 1997-0160                                                                                         
              Application No. 08/073,985                                                                                   




                                                    BACKGROUND                                                             
                     According to appellants,                                                                              
                     [i]n the presently claimed invention, bacterial RNA is hybridized with a primer                       
                     which is complementary to a genus specific region of RNA of a particular                              
                     bacteria.  The 3' end of this primer is not complementary to the RNA of                               
                     bacteria from another genus.  If bacteria of the genus to be detected are                             
                     present in the sample, the hybridized primer is elongated in the presence of                          
                     a suitable polymerase and deoxyribonucleotides.  Any elongation product                               
                     which is formed is then hybridized with a labeled oligonucleotide which is                            
                     specific for a particular species within the detected genus.  The hybridization                       
                     product is then detected by means of the labeled oligonucleotide.  [Brief, p.                         
                     5.]                                                                                                   
                                                        OPINION                                                            
                     As set forth in In re Vaeck, 947 F.2d 488, 493, 20 USPQ2d 1438, 1442                                  
              (Fed. Cir. 1991),                                                                                            
                     [w]here claimed subject matter has been rejected as obvious in view of a                              
                     combination of prior art references, a proper analysis under § 103 requires,                          
                     inter alia, consideration of two factors: (1) whether the prior art would have                        
                     suggested to those of ordinary skill in the art that they should make the                             
                     claimed composition or device, or carry out the claimed process; and (2)                              
                     whether the prior art would also have revealed that in so making or carry out,                        
                     those of ordinary skill would have a reasonable expectation of success.  See                          
                     In re Dow Chemical Co., 837 F.2d 469, 473, 4 USPQ2d 1529, 1531 (Fed.                                  
                     Cir. 1988).  Both the suggestion and the reasonable expectation of success                            
                     must be founded in the prior art, not in the applicant's disclosure.  Id.                             
              Mullis, Hogan and Frohman are applied as prior art against the claimed invention.                            




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