Ex parte CLEMENCE et al. - Page 6




              Appeal No. 1997-1280                                                                Page 6                
              Application No. 08/356,912                                                                                


                     Appellants have asserted that there is a showing of unexpected properties in the                   
              Declarations of record.  We determine that the argument is unpersuasive, because the                      
              species utilized in the Declaration, N-[2,3-dihydro-2-(1-pyrrolidinyl)-1H-inden-1-yl]-3,4-                
              dimethoxy-N-methyl-benzene- acetamide, representative of the prior art, is not prepared by                
              Pennev.  Moreover, Pennev clearly teaches another species, N-[2,3-dihydro-2-(1-                           
              pyrrolidinyl)-1H-inden-1-yl]-3,4-dichloro-N-methyl-benzene- acetamide within the scope of                 
              the claimed subject matter other than for the presence of the 3,4-dichloro groups.  See                   
              Example 6.  We determine that Example 6 is the closest example to the claimed subject                     
              matter.  Moreover, the compound of Example 6, is also one of the appellants preferred, but                
              unclaimed compounds.  See specification, page 5, lines 6-8.  Hence, the comparative                       
              examples which fail to include that compound do not reflect the closest prior art relied upon             
              in our opinion.  In re Baxter Travenol Labs., 952 F.2d 388, 392, 21 USPQ2d 1281, 1285                     

              (Fed. Cir. 1991); In re De Blauwe, 736 F.2d 699, 705, 222 USPQ 191, 196 (Fed. Cir.                        
              1984).  In addition, it is well settled that direct or indirect testing between the claimed               
              compounds and the closest prior art may be necessary.  In re Merchant 575 F.2d 865,                       

              869, 197 USPQ 785, 788 (CCPA 1978).                                                                       
                     Furthermore, each of the tests conducted by declarant Fortin, uses the same single                 
              species of prior art compound.  i.e., N-[2,3-dihydro-2-(1-pyrrolidinyl)-1H-inden-1-yl]-3,4-               
              dichloro-N-methyl-benzene- acetamide.  It is well settled that, “where an applicant tests less            









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