Ex parte BEER et al. - Page 3




            Appeal No. 1997-1849                                                                              
            Application 08/414,180                                                                            



                   50.  A method for treatment of drug dependence caused by alcohol or cocaine                
            abuse, which comprises administering to a human or animal suffering from or dependent             
            on a drug, an effective amount of the compound of the formula:                                    





                                                                                                             



            in which R is hydrogen or alkyl of 1 - 6 carbon atoms;                                            
                    1                                                                                         
                   R  is hydrogen or one or two substituents selected from the halogens, alkoxy of 1 to       
            3 carbon atoms, CF  or alkyl of 1 - 6 carbon atoms; and                                           
                               3                                                                              
                    2                                                                                         
                   R  is hydrogen, methyl or ethyl;                                                           
            or a pharmaceutically acceptable salt thereof.                                                    

                                          REFERENCE CITATION                                                  
                   In responding to the examiner's rejection under 35 U.S.C. § 112, first paragraph,          
            applicants rely on the following reference:                                                       
            Amit et al. (Amit), “Serotonin Uptake Inhibitors: Effects on Motivated Consummatory               
            Behaviors,” J. Clin. Psychiatry, Vol. 52, No. 12 (Suppl.), pp. 55-60 (Dec. 1991).                 






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