Ex parte FLAUGH - Page 2




            Appeal No. 1997-1954                                                                              
            Application 08/154,903                                                                            









            wherein                                                                                           
                    1                                                                                         
                   R  is hydrogen, C -C  alkyl or C -C  alkoxy;1  4        1  4                                                         
                    2                                                                                         
                   R  is hydrogen or C -C  alkyl;                                                             
                                      1  4                                                                    
                    3                                                                                         
                   R  is hydrogen, C -C  alkyl, phenyl or substituted phenyl;                                 
                                    1  4                                                                      
                    4                                                                                         
                   R  is hydrogen, haloacetyl, C -C  alkanoyl, benzoly or benzoyl substituted with halo       
                                               1  5                                                           
            or methyl;                                                                                        
                    5       6                                                                                 
                   R  and R  are each independently hydrogen or halo; and                                     
                    7                                                                                         
                   R  is hydrogen or C -C  alkyl;                                                             
                                      1  4                                                                    
                                       2                              5      6                             
                   provided that when R  is hydrogen then at least one of R  and R  is halo.                  
                   The references relied upon by the examiner are:                                            
            Short et al. (Short)             4,600,723          July  15, 1986                                
            Flaugh                           4,997,845          March 5, 1991                                 
                   An additional reference discussed by this merits panel is:                                 
            Frohn et al. (Frohn), “Structure-Activity Relationship of Melatonin Analogues,”                   
            Life Sciences, Vol. 27, No. 22, pp. 2043-2046 (1980).                                             






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