Ex parte FLAUGH - Page 3




            Appeal No. 1997-1954                                                                              
            Application 08/154,903                                                                            

                   Claims 1 through 22 stand rejected under 35 U.S.C. § 112, first paragraph                  
            (enablement).  Claims 1 through 22 also stand rejected under 35 U.S.C. § 103.  As                 
            evidence of obviousness, the examiner relies upon Short and Flaugh.  We reverse                   
            the rejection under 35 U.S.C. § 112, first paragraph, and vacate the rejection under              
            35 U.S.C. § 103.  In addition, we raise other issues for the examiner to consider upon            
            return of the application.                                                                        
                                             BACKGROUND                                                       
                   Melatonin is a known compound with several different uses, e.g., ovulation inhibitory      
            activity, expedite recovery from “jet lag syndrome,” cause sleep, and minimize                    
            disturbances in circadian rhythms of bodily performance and function.  See page 1 and             
            lines 1-3 of page 2 in the specification.  On page 13, lines 33-38, the specification             
            incorporates by reference two patents which discuss desynchronized circadian rhythms              
            and causes of the same including Short which is relied upon by the examiner in rejecting          
            the claims under 35 U.S.C. § 103.                                                                 
                   The claimed invention is directed to a method of treating desynchronization                
            disorders in a mammal suffering or susceptible to such disorders which comprises                  
            administering to the mammal an effective amount of a compound having the formula as               
            recited in claim 1.  The claimed compounds can be termed analogs or derivatives of                
            melatonin.                                                                                        
                                             DISCUSSION                                                       

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