Ex Parte DONG et al - Page 11




                 Appeal No. 1997-2139                                                                                                                
                 Application No. 08/114,595                                                                                                          


                          Accordingly, the rejection of claims 1-6, 8-26, 29-34, 36-40 and 42-46 under 35                                            
                 U.S.C. § 103 as being unpatentable over Haj-Ahmad and Muzyczka is reversed.                                                         
                 3.       Rejection of claims 7 and 35 under § 103 over Haj-Ahmad, Muzyczka and Post                                                 
                 4.       Rejection of claims 27, 28 and 41 under § 103 over Haj-Ahmad, Muzyczka and                                                 
                          Drumm                                                                                                                      
                          The examiner relies on Post to suggest using a herpes virus as an alternative to                                           
                 adenovirus as a vector for delivering genes; and, on Drumm for disclosing CFTR cDNA                                                 
                 and suggesting its use in treating cystic fibrosis (answer, pp. 6-8).  However, the                                                 
                 examiner has not pointed out, and we do not find where, Post and/or Drumm disclose                                                  
                 or suggest the required limitation of a recombinant adenovirus or herpesvirus vector                                                
                 comprising an essential AAV gene capable of expressing an essential AAV protein.                                                    
                          Accordingly for the reasons stated above, we do not sustain any of the                                                     
                 examiner's rejections of claims 1-46 under 35 U.S.C. § 103 as unpatentable over any                                                 
                 combination based on Haj-Ahmad and Muzyczka.                                                                                        













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