Ex parte KOSLEY JR. et al. - Page 15




          Appeal No. 1997-2167                                                        
          Application 08/137,444                                                      
               Simply stated, the examiner has failed to present                      
          objective evidence sufficient to cast doubt on the objective                
          truthfulness of appellants' assertions made in their                        
          specification and on which they rely for enablement.  It is                 
          only after the examiner presents evidence which establishes                 
          that one of ordinary skill in the art would reasonably doubt                
          the assertions made by appellants in their specification in                 
          support of the enablement requirement of the statute that                   
          appellants must rebut the position taken by the examiner.                   
               As we have noted above, on balance, the evidence on which              
          the examiner has relied gives credence to the objective                     
          truthfulness of appellants' representations rather than casts               
          doubt on them.  Moreover, the examiner has improperly narrowly              
          construed appellants' claims as limited to the treatment of                 
          Alzheimer's disease.  Both the claims and appellants'                       
          disclosure are directed generally to treating a type of memory              
          dysfunction in mammals characterized by decreased cholinergic               
          function.  The very art on which the examiner relies suggests               
          that at the time appellants made their invention, AChE                      
          inhibitors were generally recognized as a class of compounds                
          suitable for treating illness attributable to decreased                     
          acetylcholine function, including Alzheimer's disease.                      
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