Ex parte KOSLEY JR. et al. - Page 8




          Appeal No. 1997-2167                                                        
          Application 08/137,444                                                      
          inhibit AChE; and, a second where memory dysfunction                        
          characterized by decreased cholinergic function is treated                  
          with 6-O-demethylgalanthamine, a known AChE inhibiting                      
          compound, by administering to a mammal in an amount sufficient              
          to inhibit AChE the compound of Claim 2 where R  is hydrogen.3                            
          Thus, both methods are limited to treating memory dysfunction               
          characterized by decreased cholinergic function.                            
               The first method requires administering to a mammal with               
          memory dysfunction characterized by decreased cholinergic                   
          function an amount of the compound of claim 1 sufficient to                 
          inhibit the formation in the mammal of the enzyme AchE.  As a               
          "comprising" claim the first method does not exclude any other              
          step or ingredient, including steps or ingredients disclosed                
          but not claimed and even steps or ingredients neither                       
          disclosed or even contemplated.  The second method requires                 
          administering to a mammal with memory dysfunction                           
          characterized by decreased cholinergic function the compound                
          6-O-demethylgalanthamine by administering to said mammal in an              
          amount sufficient to inhibit the formation in the mammal of                 
          AChE the compound of Claim 2 or 31 which metabolizes to 6-O-                
          demethylgalanthamine.  Like the first method, the second                    
          method is open to other steps and ingredients, both disclosed               
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