Appeal No. 1997-2167
Application 08/137,444
THE INVENTION
The appealed subject matter is directed to a genus of
compounds which may be broadly characterized as galanthamine
derivatives, pharmaceutical compositions comprising a
pharmaceutically acceptable carrier and an
acetylcholinesterase (AChE) inhibiting amount of the
galanthamine derivative, methods of treating memory
dysfunction characterized by decreased cholinergic function by
administering to a mammal an AChE inhibiting amount of the
galanthamine derivative and methods of treating memory
dysfunction characterized by decreased cholingeric function by
administering to a mammal an AChE inhibiting amount of the
galanthamine derivative which metabolizes in situ to form 6-O-
demethylgalanthamine. According to appellants, the claimed
family of galanthamine derivatives possesses the ability to
inhibit the enzyme AchE. The enzyme AChE lowers acetylcholine
levels in the brain. Inhibition of AChE therefore increases
brain levels of acetylcholine.
Claims 1, 2, 48, 49 and 50 are believed to be adequately
representative of the appealed subject matter and are
reproduced below for a more facile understanding of
2
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