Ex parte GOLDENBERG - Page 3




             Appeal No. 1997-2368                                                                                 
             Application 08/158,782                                                                               


                    Claims 1, 3-6, 8-10, 19, 20, 24, 25, 39-44, and 46-48 stand rejected under the                
             judicially created doctrine of obvious-type double patenting as being unpatentable over              
             claims 1-29 of U.S. Patent 5,332,567 to Goldenberg.                                                  
                    We reverse.                                                                                   
                                                BACKGROUND                                                        

                    The invention is described by applicants, at pages 4 and 8 of the specification, as           
             being directed to a method of targeting a therapeutic agent to a focus of infection which            
             comprises injecting an infected patient with an antibody conjugate, the antibodies of which          
             specifically bind to accessible epitopes of a pathogen associated with the infection or a            
             pathogen-associated antigen, wherein the conjugate is comprised of a plurality of                    
             chemically linked antibodies or fragments thereof and a chemically linked therapeutic                
             agent.  The use of the conjugate in the manner claimed is stated to result in an increased           
             likelihood that the therapeutic agent will reach the site of the infection.                          


                                                  DISCUSSION                                                      

                                       The rejection under 35 U.S.C. § 103                                        
                    In rejecting claims under 35 U.S.C. § 103, the examiner bears the initial burden of           
             presenting a prima facie case of obviousness.  In re Oetiker, 977 F.2d 1443, 1445, 24                
             USPQ2d 1443, 1444 (Fed. Cir. 1992).  Only if that burden is met, does the burden  of                 


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