Appeal No. 1997-2436
Application No. 08/232,014
interface between said water phase and said oil phase either of a water-in-oil emulsion or
an oil-in-water emulsion, and forming said nanocapsules or nanoparticles from said
nanoemulsion, wherein an interfacial crosslinking reaction is carried out, between said
protein and a crosslinking agent having reactive groups capable of reacting at said
interface with said acylatable groups of said protein, so as to yield said nanocapsules with
crosslinked protein-based walls.
24. A process for the production of nanocapsules, with cross-linked protein-
based walls, which comprises preparing a nanoemulsion of said proteins comprising an
oil phase and a water phase, defining an interface between said water phase and said oil
phase either of a waste-in-oil emulsion or of an oil-in-water emulsion and forming said
nanocapsules from said nanoemulsion, wherein an interfacial cross-linking reaction is
carried out between said proteins and a cross-linking agent selected from the group
consisting of an acid dichloride, an acid anhydride and a dibasic or polybasic carboxylic
acid, as to yield said nanocapsules, with cross-linked protein-based walls.
36. A nanocapsule or nanoparticle having a size of less than 800 nM comprising
a crosslinked outer wall having been obtained from a nanoemulsion by an interfacial
crosslinking reaction between at least one protein having acylatable groups and a
crosslinking agent having reactive groups capable of reacting with said acylatable groups
of said protein to form interfacial crosslinking.
The reference relied upon by the examiner is:
Huc et al. (Huc) 5,395,620 March 7, 1995
(Filed June 8, 1993)
Grounds of Rejection
Claims 3-7, 11, 14-17, 21-29, 31, 34, 36-44, 46, and 47 stand rejected under
35 U.S.C. § 102 (e). As evidence of anticipation, the examiner relies upon Huc.
Claims 3-50 stand rejected under 35 U.S.C. § 103. As evidence of obviousness the
examiner relies upon Huc.
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