Appeal No. 1997-2829 Application No. 08/456,090 psychological effects (Kreutner, col. 1, lines 42-52; col. 1, line 67, to col. 2, line 2); and (5) Kreutner strongly suggests that baclofen can inhibit chemically, mechanically, or electrically-induced cough (Kreutner, col. 6, lines 45-51). The examiner further states that "optimization of amounts of ingredients to be used is deemed within the skill of the artisan" (Answer, Paper No. 11, paragraph bridging pages 5 and 6). 3. With respect to Group I, claims 1-6, appellant argues the following: a. Kreutner is silent respecting the treatment of coughs induced by ACE inhibitors ( Brief, page 2, line 28, to page 3, line 4). However, as set forth in section VI-B2, supra, Kreutner does not limit the source of the cough. Kreutner strongly suggests that baclofen can inhibit chemically, mechanically, and electrically-induced cough (Kreutner, col. 6, lines 45- 51). Further, as discussed, supra, Kreutner discloses that (1) baclofen has unexpectedly surprising activity as an antitussive agent (Kreutner, col. 1, lines 65-67); (2) baclofen has demonstrated cough suppressing activity -10-Page: Previous 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 NextLast modified: November 3, 2007