Ex parte DICPINIGAITIS - Page 15




          Appeal No. 1997-2829                                                        
          Application No. 08/456,090                                                  


          the dosage, e.g., the amount, frequency and duration of                     
          baclofen required to suppress coughing, such as that induced                
          by ACE inhibitors.  (If a headache persists after                           
          administering a single dosage of aspirin, more aspirin is                   
          usually taken until the headache is gone.)                                  
               The rejection of claims 1-6 under 35 U.S.C. § 103 over                 
          Kreutner is affirmed.                                                       
               4.  Appellant argues that claim 13 is patentable for the               
          following reasons:                                                          
               a.  Claim 13 recites administering from 10 to 30 mg daily              
          of baclofen for about three days to suppress the cough                      
          associated with the administration of an ACE inhibitor; and                 
               b.  The Rule 132 Declaration provides evidence that                    
          baclofen has no effect on ACE inhibitor induced coughing until              
          three days have elapsed.  See Brief, Paper No. 10, paragraph                
          bridging pages 4 and 5.                                                     
               However, as set forth in section VI-B2, supra, Kreutner                
          discloses that baclofen can be administered from 5 to 5000                  
          mg/day, preferably from 10 to 1000 mg/day, to achieve relief                
          of cough (Kreutner, col. 3, lines 53-57).  Appellant at page                
          3, lines 21-23 of the Brief, acknowledges that this "embraces"              


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