Appeal No. 1997-2829
Application No. 08/456,090
skill of the art (Kreutner, col. 3, lines 58-60). Kreutner
teaches that the amount and frequency of the administration of
baclofen will be regulated according to the judgment of the
attending clinician with respect to the age, condition and
size of the patient, and the severity of the symptom being
treated (Kreutner, col. 3, line 66, to col. 4, line 3).
Kreutner does not specifically address coughs induced by
the administration of an ACE inhibitor. However, Kreutner
does not limit the source of the cough. According to
Kreutner, baclofen has unexpectedly surprising activity as an
antitussive agent (Kreutner, col. 1, lines 65-67). Baclofen
has demonstrated cough suppressing activity significantly
(about 14 to 40 times) better than codeine in the tests
performed by Kreutner (Kreutner, col. 3, lines 2-5; col. 6,
lines 8-12). Administering baclofen in an antitussive
effective amount avoids the possible side effects caused by
GABA-A agonism, such as motor-incoordination, confusion,
light-headedness, and other adverse psychomotor and
psychological effects (Kreutner, col. 1, lines 42-52; col. 1,
line 67, to col. 2, line 2). Kreutner strongly suggests that
-8-
Page: Previous 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 Next
Last modified: November 3, 2007